# DORMIR: Determinants, Outcomes, Responses and Markers of  Insufficient sleep in Rural-Urban settings

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $816,381

## Abstract

Project Summary
The widening gap in all-cause and CVD-mortality and morbidity rates in rural and urban America is at an all-
time high. Latino/as, the largest minority ethnic group in the U.S., appear to be most affected by rural-urban
divide in CVD outcomes, as they are disproportionately burdened by CVD risk (overweight/obesity,
hypertension, dyslipidemia, diabetes) and CVD mortality (20%, 2nd leading cause of death among Latino/as)
relative to other racial/ethnic groups. Unlike other groups where individuals in rural and urban areas have
differing CVD risk, rural and urban Latino/as have similarly high rates of CVD risk. Although, healthy diets/
nutrition, smoking cessation, and regular physical activity are linked to CVD risk, they have not been very
effective in reducing the CVD burden among racial/ethnic groups, specifically among Latino/as. Several studies
indicate that insufficient sleep (<7hrs./day) explains a significant amount of the CVD burden among Latino/as.
Preliminary evidence indicates that insufficient sleep may contribute to the observed CVD burden among
Latino/as, as Latino/as have greater odds of experiencing insufficient sleep compared with non-Hispanic
whites. Evidence also shows that insufficient sleep, which is associated with potentially life-threatening CVD,
is a key modifiable risk factor with great potential to reduce health disparities. However, it is unclear what
factors contribute to insufficient sleep (IS) disparities and IS-related CVD burden among rural and urban
Latino/as. To address these gaps, we will enroll 525 Latino/as in rural and urban communities to participate in
home-based studies using novel mHealth devices. The multidisciplinary team will: 1) identify behavioral,
genetic, psychosocial, and environmental factors that are associated with insufficient sleep and IS-related CVD
and 2) assess effects of insufficient sleep on CVD risk markers (obesity, blood pressure, lipid profile, and
fasting plasma glucose/ HbA1C) and inflammatory risk markers (IL-6, IL-10, and TNF-α). This study will
provide multi-level evidence supporting epidemiological findings of greater rates of insufficient sleep among
Latino/as, which may explain their disproportionate burden of CVD risk. It will also assess whether and why
rural and urban differences in IS exist among Latino/as and how that may lead to IS-related CVD outcomes.
These data will provide: 1) the foundation for interventions to mitigate adverse effects of insufficient sleep on
CVD health outcomes, 2) evidence to delineate factors underlying insufficient sleep and CVD burden among
Latino/as in rural and urban settings, and 3) a possible explanation of behavioral, genetic, environmental and
psychosocial determinants of insufficient sleep and related CVD risk factors in rural and urban Latino/as.
Findings can lead to actionable clinical, lifestyle, and policy interventions to improve Latino health.

## Key facts

- **NIH application ID:** 10254265
- **Project number:** 5R01HL152453-02
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Azizi Seixas
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $816,381
- **Award type:** 5
- **Project period:** 2020-09-05 → 2021-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10254265

## Citation

> US National Institutes of Health, RePORTER application 10254265, DORMIR: Determinants, Outcomes, Responses and Markers of  Insufficient sleep in Rural-Urban settings (5R01HL152453-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10254265. Licensed CC0.

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