# LARGE SCALE T CELL EPITOPE DISCOVERY - COVID Supplement

> **NIH NIH N01** · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2020 · $650,336

## Abstract

The SARS-CoV-2 epitope Megapools (SARS-CoV-2 MPs) is used to study SARS-CoV-2 CD4 and CD8 specific T cell responses. The Megapool (MP) approach allows simultaneous testing of large number of epitopes. According to this approach large numbers of different epitopes are solubilized, pooled and re-lyophilized to avoid cell toxicity problems associated with high concentrations of DMSO typically encountered when single pre-solubilized epitopes are pooled. These MPs have been used for both CD4 and CD8 T cell epitope identification.

## Key facts

- **NIH application ID:** 10254455
- **Project number:** 75N93019C00065-P00002-9999-2
- **Recipient organization:** LA JOLLA INSTITUTE FOR IMMUNOLOGY
- **Principal Investigator:** ALESSANDRO SETTE
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $650,336
- **Award type:** —
- **Project period:** 2019-09-30 → 2020-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10254455

## Citation

> US National Institutes of Health, RePORTER application 10254455, LARGE SCALE T CELL EPITOPE DISCOVERY - COVID Supplement (75N93019C00065-P00002-9999-2). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10254455. Licensed CC0.

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