ABSTRACT This proposal describes the application of The Ohio State University (OSU) Center for continued participation in the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network. The current application describes our team, environment and resources to meet the objectives of the Network. Since 1992, the OSU Center has demonstrated a strong performance and experience in conducting clinical and translational research based on excellent infrastructure and institutional support. We developed a strong research team led by Maged Costantine, MD who was recruited to the OSU Wexner Medical Center in 2019, as a Division Director for Maternal Fetal Medicine and Principal Investigator for the MFMU Network Center, and Mark Landon, MD who serves as Chair for the Department of OG/GYN and Alternate PI. In addition to productivity in the MFMU Network, both the PI and alternate PI, bring extensive experience in study design, recruitment, data analysis, and publications. The OSU Network will recruit study participants from diverse populations at 3 medical centers with a combined total of more than 15,000 annual births, many of them are high-risk, and the majority receiving prenatal care at the three systems. Our Center Nurse Coordinator, Anna Bartholomew, MPH, RN, BSN, CCRP, leads a large group of faculty & research staff capable of recruiting and retaining patients in the setting of an excellent research organization enhanced by 29 years of experience in the MFMU Network, participation in the NICHD Nulliparous Network, and memberships in the North American Fetal Treatment Network, and Ohio Perinatal Research Network (OPRN). We benefit from a robust bioinformatics structure and versatile Electronic Medical Record System (EMR) that captures antepartum, intrapartum, and postpartum data online and is readily available to authorized research personnel for query as well as automatic notification, an extraordinary group of obstetrical sonographers, perinatal epidemiologists, and a mature research infrastructure supported by a CTSA grant shared with Nationwide Children’s Hospital. Our satellite sites, Miami Valley Hospital in Dayton and Good Samaritan Hospital in Cincinnati, have an outstanding record of recruitment in the most recent Network cycle, well-established research culture, and ambitious goals for MFMU Network participation. Our partnership and strong collaboration with Neonatology at Nationwide Children’s Hospital in clinical care and research, Pathology and Clinical Laboratory add strengths to our application. We look forward to continuing our tradition of service, strong performance, and innovation in the next cycle of the NICHD MFMU Network. We accept the RFA’s capitation and participatory stipulations and stand ready to achieve the goals of the Network in completion of the ongoing studies in a collaborative way across all research centers.