PROJECT SUMMARY/ABSTRACT South Dakota Biomedical Research Infrastructure Network (SD BRIN), hosted by Sanford School of Medicine of the University of South Dakota in Vermillion, SD is the SD component of IDeA Networks of Biomedical Research Excellence (INBRE) funded by the NIH/NIGMS Institutional Development Award (IDeA) program. This proposal evolved from insights gained and enhancements made during the previous phases of BRIN/INBRE. The two main goals for this phase of SD BRIN are the same as those developed based on research history and needs in the previous phases. SD BRIN envisions a continued robust interdisciplinary collaborative network within SD to enhance basic biomedical research capabilities in cell biology and control of cell growth. The vision emphasizes bioinformatics, proteomics and genomics/genetics core facilities located at either the lead institution or at Black Hills State University (a predominantly undergraduate institutional partner housing the Nucleic Acid Sequencing and Genotyping Core Facility (WestCore). Therefore, the aims of this phase of INBRE in South Dakota are to: 1) Continue to develop the research capacity of South Dakota in the area of cell biology and the control of cell growth with special emphasis on proteomics and genomics by: a) enhancing the research capacity of investigators in proteomics, b) maintaining proteomics, bioinformatics, and nucleic acid sequencing and genotyping core facilities (with professional staff) accessible to investigators throughout SD (and other IDeA states), and c) offering opportunities for graduate training in proteomics, nucleic acid sequencing, and bioinformatics, and d) supporting access to online library scientific databases to all faculty and students from all SD BRIN participating institutions. 2) Develop human resources for undergraduate and graduate programs in the biomedical sciences and bioinformatics by helping to instill a culture of research and provide a pipeline for students interested in biomedical research at South Dakota’s predominantly undergraduate institutions and tribal colleges by: a) providing research support and mentoring for faculty from participating institutions, b) providing opportunities for, and understanding of, cutting-edge scientific research for students at participating institutions, c) introducing undergraduates to graduate programs and future careers in biomedical sciences and bioinformatics, and d) enhancing science education and research capabilities at tribal colleges, providing opportunities for further education and careers in science and research.