# Development of CoroDetecT, a skin test for SARS-CoV-2 infection

> **NIH NIH R43** · HDT BIO CORPORATION · 2021 · $223,637

## Abstract

The following contains proprietary/privileged information that HDT Bio Corp requests not be
released to persons outside the government, except for purposes of review and evaluation.
PROJECT SUMMARY/ ABSTRACT
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, the cause of the COVID-19 pandemic, rapidly
spread worldwide and has had, and continues to have, a devasting impact on the global economy and individual quality
of life. Large scale testing and expedient testing at regional and national levels is required for improved
understanding of SARS-CoV-2 infection levels to inform public health control measures and guide a return to
normality. While diagnostic strategies using nucleic acid- and antibody-detection tests have emerged, practical
and scientific/clinical limitations inherent to both these platforms have left testing gaps. The rapid waning of
antibody titers that is a natural phenomenon common to coronavirus immunity has been reported after SARS-
CoV-2 infection (3-5), limiting the capability of antibody-based tests to assess both infection and immunity.
Detailed immunological evaluations are, however, now indicating that antigen-specific T cell responses
generated by both symptomatic and asymptomatic SARS-CoV-2 infection are more stable and longer lasting.
Thus, there is significant merit in developing commercial tests that detect antigen-specific T cell responses for
integration into the overall COVID-19 epidemiology and containment strategy. The overall goal of this program
is to develop a T cell-based skin test (CoroDetecTTM) to detect and assess history of SARS-CoV-2-infection.
Importantly, unlike most other testing systems, we will emphasize the production of a test that has minimal
components, does not require laboratory support, and provides results directly to the subject being tested.

## Key facts

- **NIH application ID:** 10256151
- **Project number:** 1R43AI162278-01
- **Recipient organization:** HDT BIO CORPORATION
- **Principal Investigator:** MALCOLM S DUTHIE
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $223,637
- **Award type:** 1
- **Project period:** 2021-03-16 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10256151

## Citation

> US National Institutes of Health, RePORTER application 10256151, Development of CoroDetecT, a skin test for SARS-CoV-2 infection (1R43AI162278-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10256151. Licensed CC0.

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