# Fully Automated Basic Life Services Resuscitation System to Improve Survival after Cardiac Arrest

> **NIH NIH R43** · ADVANCEDCPR SOLUTIONS LLC · 2021 · $383,376

## Abstract

Abstract
The overall goal of this application is to improve neurologically-intact survival rates after sudden cardiac arrest
(SCA). Still a leading cause of death, <10% of the more than 600,000 SCA patients in the US each year survive
with favorable neurological function. We propose to develop and evaluate a novel comprehensive Head Up
(HUP) cardiopulmonary resuscitation (CPR) System designed primarily to allow Basic Life Services (BLS)
providers (a fire crew without paramedics) to rapidly deliver fully automated CPR, including for the first time,
automated synchronized mechanical positive pressure ventilation (PPV), to increase the likelihood of
neurologically intact survival after SCA and increase crew safety. The proposal focuses on further developing
and delivering an innovative all-in-one device for BLS teams based on our most recent breakthroughs in
optimizing brain perfusion during SCA using controlled sequential elevation of the head and thorax in
combination with the use of Active Compression Decompression (ACD) CPR and an impedance threshold device
(ITD). As demonstrated in a well-accepted porcine SCA model, HUP CPR combined with ACD CPR and an ITD
uniquely harnesses gravity to enhance drainage of venous blood from the head and neck, lower intracranial
pressure, and markedly increase systemic and cerebral blood flow and likelihood for survival. The overall
objectives of this application are also supported by new clinical data from a CPR Registry of patients receiving
HUP CPR suggesting this comprehensive approach may provide the most benefit when deployed rapidly.
Moreover, in resource-strapped Emergency Medical Services (EMS) systems across the country there is a
growing need to develop technology that minimizes the number of resources required to deliver high quality CPR
that is best for patient outcomes and safer for rescue personnel. We propose to achieve these collective
objectives by demonstrating that incorporation of automated positive pressure ventilation (PPV), synchronized
to the decompression phase of an easy to deploy and fully automated HUP CPR system, is feasible and safe for
BLS providers, will reduce CPR personnel resource requirements, and most importantly, will optimize chances
for neurologically intact survival after SCA. This combination of innovations, described herein as the SAVE CPR
System, represents the combination of Synchronization, ACD+ITD, Ventilation, and Elevation. As such, the
Specific Aims are: 1) Design and prototype an improved Head Up CPR device which includes automated PPV
that is synchronized with the decompression phase of ACD CPR; 2) Determine if the SAVE CPR System will
increase 24-hour survival with favorable brain function when implemented immediately after 10 minutes of
untreated cardiac arrest compared with a delayed implementation strategy whereby SAVE is initiated after 10
minutes of untreated cardiac arrest and 8 minutes of conventional CPR to simulate Advanced Life Support (ALS)
rather t...

## Key facts

- **NIH application ID:** 10256435
- **Project number:** 1R43HL158361-01
- **Recipient organization:** ADVANCEDCPR SOLUTIONS LLC
- **Principal Investigator:** Keith Lurie
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $383,376
- **Award type:** 1
- **Project period:** 2021-09-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10256435

## Citation

> US National Institutes of Health, RePORTER application 10256435, Fully Automated Basic Life Services Resuscitation System to Improve Survival after Cardiac Arrest (1R43HL158361-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10256435. Licensed CC0.

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