# Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

> **NIH NIH U01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $1,732,423

## Abstract

Project Summary Abstract
Lung cancer remains the leading cause of cancer related mortality in the US and globally—
responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer
Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we
have contributed to the development of US national strategies for reducing the lung cancer
burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall
mortality, and by evaluating the population benefits and harms of lung cancer screening in the
US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to
continue declining. However, lung cancer is still expected to result in over 4 million deaths over
the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and
treatment interventions will be critical to further reduce the lung cancer burden in the US.
Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there
are concerns that the gains achieved in the fight against smoking could reverse. We propose to
continue our work and extend our models to assess the impact of 1) future tobacco control
interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer
screening and other emerging early detection strategies, 3) innovations in lung cancer
treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall
mortality in the US and globally.

## Key facts

- **NIH application ID:** 10256749
- **Project number:** 5U01CA253858-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** THEODORE R HOLFORD
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,732,423
- **Award type:** 5
- **Project period:** 2020-09-08 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10256749

## Citation

> US National Institutes of Health, RePORTER application 10256749, Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions (5U01CA253858-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10256749. Licensed CC0.

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