# Administrative Core

> **NIH NIH U2C** · DANA-FARBER CANCER INST · 2021 · $403,118

## Abstract

The overarching goal of the Boston Human Tumor Atlas Network Research Center (HTA-RC) is 
to create three comprehensive atlases of the cellular geography of human melanoma, 
colorectal cancer, and breast cancer, to understand how changes in the tumor ecosystem 
lead each to therapeutic resistance. The atlases will map the topography of the number, nature, 
and spatial relationship of cells and histological structures that distinguish those tumors resistant 
to targeted and immune-based therapies. The Administrative Core will be responsible for the 
leadership, governance, and accountability of the Boston HTA-RC. The Core will coordinate and 
evaluate each component of the Research Center (RC); provide operational oversight of all 
aspects of the program; and monitor progress toward milestones. In particular, the Core will 
Provide overall management and coordination of RC activities (Aim 1). It will monitor 
progress toward the milestone goals, oversee financial expenditures, and provide support for all 
facets of the Center's activities, through: liaising closely with the Center's leadership and unit 
leads; project management and fiscal oversight; and on-going guidance from a local steering 
committee comprising domain experts in relevant fields. The core will also provide logistical 
support and facilitate communication within and outside the RC (Aim 2), to ensure dynamic 
interaction between all elements of the Center. A project manager will oversee flow of information, 
physical samples, and technologies between Units, leveraging both state-of-the-art electronic 
tracking systems, live and transparent aids, and active interaction through regular leadership 
meetings, steering committee meetings, an external advisory board, and an annual retreat. The 
Boston HTA-RC will be deeply embedded in the vibrant clinical and scientific communities at 
DFCI, Broad, and Massachusetts General Hospital (MGH), Harvard, and Stanford, and the Core 
will also be responsible for communication with the broader HTA network, the Data Coordinating 
Center, and the NCI. Finally, the core will evaluate progress toward milestones (Aim 3), based 
on a series of quantitative milestones we developed. It will assess milestone progress on a regular 
basis, provide reports to the Leadership Team, and develop proposals for any blocking issues or 
milestone revisions needed for discussions with NCI Program Officials.

## Key facts

- **NIH application ID:** 10259736
- **Project number:** 5U2CCA233195-04
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** BRUCE E. JOHNSON
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $403,118
- **Award type:** 5
- **Project period:** 2018-09-24 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10259736

## Citation

> US National Institutes of Health, RePORTER application 10259736, Administrative Core (5U2CCA233195-04). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10259736. Licensed CC0.

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