# Organ Specific Project

> **NIH NIH U54** · BATTELLE PACIFIC NORTHWEST LABORATORIES · 2021 · $702,096

## Abstract

PROJECT ABSTRACT
The overarching goal of the Human BioMolecular Atlas Program (HuBMAP) and specifically of Tissue Mapping
Centers is to generate high resolution 3D biomolecular maps for non-diseased human organs. The overall
objective of this pancreas organ specific project (OSP) is to identify and collect whole disease-free pancreas
from donors across different sexes and ethnicities, to develop a robust system for tissue processing and
distribution, and to generate multi-scale, high resolution, 3D multi-omics molecular atlases of functional
regions of human pancreas.
This OSP integrates unique expertise ranging from pancreas biology, diabetes, organ procurement, tissue
processing, deep-tissue fluorescence imaging analysis (University of Florida), advanced multi-omics mass
spectrometry-based tissue mapping (PNNL), and sophisticated high-throughput bioinformatics and 3D
reconstruction of molecular maps (Texas Advanced Computing Center) of regions of pancreas, such as islets.
Specifically, we will: (1) Identify and collect whole disease-free pancreas from donors through collaboration
with the Organ Procurement Organizations (OPO) and Research Intermediaries (RI), and develop
infrastructure for timely referral and donor collection, as well as a robust, web-based, specimen inventory and
request system that accesses a catalogue of representative sample derivative meta-data (i.e. whole slide image
or cytometry) of quality and composition; (2) Provide preserved, embedded, and sectioned pancreas tissue
using pancreatic processing processes that have carefully mapped the pancreas in 2D; (3) Perform multi-scale
and multi-omic imaging or spatially resolved characterization of pancreas and function-guided tissue sections
through the characterization pipeline; and (4) Create comprehensive 3-D biomolecular atlas of pancreas that
maps protein, metabolite, and lipid expression throughout functional regions of the pancreas through the Data
Analysis Core.

## Key facts

- **NIH application ID:** 10259784
- **Project number:** 5U54DK127823-02
- **Recipient organization:** BATTELLE PACIFIC NORTHWEST LABORATORIES
- **Principal Investigator:** CLAYTON E MATHEWS
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $702,096
- **Award type:** 5
- **Project period:** 2020-09-10 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10259784

## Citation

> US National Institutes of Health, RePORTER application 10259784, Organ Specific Project (5U54DK127823-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10259784. Licensed CC0.

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