SUPPLEMENTAL WORK - SARS-COV-2 PRECLINICAL WORK

NIH RePORTER · NIH · N01 · $1,500,152 · view on reporter.nih.gov ↗

Abstract

Chrysalis proposes to repurpose their regenerative drug, TP508, to treat COVID-19, due to its ability to reduce effects of acute lung injury, prevent normal tissue damage and reduce inflammation. TP508 has an existing efficacy profile in tissue regeneration clinical trials, an extensive safety profile (600 human subjects with no adverse effects), and is GMP manufactured with sufficient inventory to enter COVID-19 clinical trials. The drug addresses underlying causes of ARDS, including loss of endothelial function.

Key facts

NIH application ID
10259992
Project number
272201700011C-P00011-9999-2
Recipient
CHRYSALIS BIOTHERAPEUTICS, INC.
Principal Investigator
LAURIE SOWER
Activity code
N01
Funding institute
NIH
Fiscal year
2020
Award amount
$1,500,152
Award type
Project period
2020-06-05 → 2021-05-31