ABSTRACT Instrumentation Module The Instrumentation Module provides design, fabrication and modification capabilities for project-specific, customized and software-flexible vision research apparatuses that are not commercially available. During the past five years, the Module fabricated many in-house, tailor-fitted and specially-designed devices that have played crucial roles in generating many high-impact and innovative vision research results. In the next grant period, this Module will continue its indispensable role in supporting vision research projects by providing new mechanical, electronic, optic and computer-based design and fabrication services and to develop highly innovative, high-impact research tools, such as the chronically implanted recording chambers, the customized in-house construction of a 8-patch-electrode micromanipulator/recording system, two-photon microscope systems, LED white-noise stimulating system, and the forced-choice, optokinetic reflex machine. All these devices will be constructed and repeatedly modified, fitted and adjusted before and during experiments by the in-house machine shop and electronic/optics/computer shop. Therefore the Instrumentation Module is not only a necessity of many Vision Core labs, but also an integrated part of the research process and scientific progress.