# Scientific Research Resource Core

> **NIH NIH P50** · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $200,064

## Abstract

Project Summary
The breakthrough technology of CRISPR/Cas9-mediated genomic editing offers an entirely new
and powerful therapeutic potential for patients suffering from genetic diseases like Duchenne
Muscular Dystrophy (DMD). Since joining the Wellstone Network in 2015, the UT Southwestern
Myoediting Core has served both as an essential coordinating hub for the Wellstone research
groups (Projects 1 & 2) at UT Southwestern and as a conduit for sharing expertise and resources
with the broader scientific community. Moving forward, our goals for this Shared Research
Resource Core are: (Aim #1) To continue to support Projects 1 and 2 of the UT Southwestern
Wellstone Center by providing the cutting-edge technologies of human iPSCs, CRISPR/Cas9
genomic editing, and cardiomyocyte differentiation. (Aim #2) To help advance the study of
muscular dystrophy worldwide by providing a DMD/BMD Biorepository of patient-derived DMD
iPSCs and their corresponding CRISPR/Cas9-corrected isolates along with information regarding
the clinical phenotype and genomic sequence of the donor patient. (Aim #3) To help other
investigators take full advantage of these resources by freely sharing our streamlined protocols
and providing training (either on site, or in silico) in best practices and approaches. These
resources are available to investigators from other Wellstone Centers as well as the general
scientific community at large.

## Key facts

- **NIH application ID:** 10261406
- **Project number:** 5P50HD087351-07
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** RHONDA BASSEL-DUBY
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $200,064
- **Award type:** 5
- **Project period:** 2015-09-15 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10261406

## Citation

> US National Institutes of Health, RePORTER application 10261406, Scientific Research Resource Core (5P50HD087351-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10261406. Licensed CC0.

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