# CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

> **NIH NIH N01** · SRI INTERNATIONAL · 2020 · $277,194

## Abstract

This task is to conduct the core administrative activities, including project management, as well as storage
of chemical and biological inventory, archived documents and data, maintenance of equipment, and
continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF)
to support the mission of contraceptive drug development in the Contraception Research Branch (CRB),
NICHD, NIH.
The CSOF fulfills a unique role by bridging the discovery and validation of contraceptive targets to Investigational
New Drug (IND) enabling studies and subsequent clinical development and approval of contraceptive drugs. The
required research at the CSOF will encompass discovery and optimization of small molecule antagonists and/or
agonists of protein targets as anti-fertility agents and related disciplines to support that goal. This includes, but is
not limited to, assay development, high throughput screening, x-ray crystallography, computational chemistry,
medicinal chemistry, and pharmacology. This facility will also be responsible for the production of chemical
material for preliminary in vivo testing. It is expected that multiple independent projects will be performed
simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful
execution.

## Key facts

- **NIH application ID:** 10263135
- **Project number:** 275201800007I-P00002-27500001-1
- **Recipient organization:** SRI INTERNATIONAL
- **Principal Investigator:** LEYI GONG
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $277,194
- **Award type:** —
- **Project period:** 2018-09-26 → 2021-09-25

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263135

## Citation

> US National Institutes of Health, RePORTER application 10263135, CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES (275201800007I-P00002-27500001-1). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10263135. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*