# Shape Memory Polymer Scaffolds to Treat Bone Defects in Patients with Alzheimer's Disease

> **NIH NIH R03** · RENSSELAER POLYTECHNIC INSTITUTE · 2021 · $75,308

## Abstract

ABSTRACT. Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which has systemic effects.
For instance, AD patients generally suffer from low bone mineral density even in early stages of the disease,
and as such are more prone to bone fractures relative to the general population. Due to the loss in bone density,
autologous bone grafts are generally not an option in fracture repair for the AD patient population. Furthermore,
healing of fractures in AD is usually slow and often results in delayed or incomplete healing. This delayed healing
is on top of the already high complication rates often associated with defect repair. The loss in bone mineral
density in AD appears to be due in part to the abnormal peripheral sympathetic nerve (SN) activation often
associated with the disease. In particular, elevated levels of TNFα in the osteoporotic AD bone are correlated
with abnormally activate SNs, which are known to critically influence bone healing, resorption, vascularization,
and homeostasis. Thus, a biomaterial scaffold which stimulates a more normal phenotype in ingrowing SNs may
enhance osteogenesis and bone healing in AD fracture repair. Recently, we proposed a new scaffold design
based on a novel class of shape memory polymers (SMPs). Avoiding the use of exogenous factors – which can
cause undesired off-target effects - these scaffolds provide intrinsic osteoinductivity through the incorporated
adhesion ligand(s) and a nanoscale polydopamine coating known to support osteogenesis as well as the
formation of hydroxyapatite. Interestingly, polydopamine coatings have also recently been demonstrated to
stimulate extension and phenotypic maturation in SN-like cells, as have fibronectin- and laminin-derived integrin
adhesion ligands. This R03 proposal focuses on tailoring the integrin adhesion-based landscape of SMP
scaffolds to promote desired SN cell and MSC phenotypes within the context of an osteo- and neuro-inductive
polydopamine base. This proposal is unique in its focus on tailoring the phenotype of ingrowing SN cells toward
improving MSC osteogenesis and doing so within a disease-mimetic “inflamed” environment.

## Key facts

- **NIH application ID:** 10263155
- **Project number:** 5R03AG067140-02
- **Recipient organization:** RENSSELAER POLYTECHNIC INSTITUTE
- **Principal Investigator:** Melissa Grunlan
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $75,308
- **Award type:** 5
- **Project period:** 2020-09-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263155

## Citation

> US National Institutes of Health, RePORTER application 10263155, Shape Memory Polymer Scaffolds to Treat Bone Defects in Patients with Alzheimer's Disease (5R03AG067140-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10263155. Licensed CC0.

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