# Administrative Core

> **NIH NIH P50** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2021 · $326,696

## Abstract

PROJECT SUMMARY 
Gout impacts around 4% of the U.S. adult population and is the most common form of inflammatory arthritis in 
men. The incidence of gout is increasing worldwide and may be as high as 9% in the elderly. Gout is a 
significant burden on the healthcare system, and is associated with both decreased work productivity and 
quality of life. With the ever-increasing impact of gout and its associated comorbidities on the population, 
investigation of novel translational mechanisms mediating gout flares as well as approaches to improving gout 
and hyperuricemia outcomes comprise an unmet and urgent medical need. The Administrative Core is 
responsible for the focusing the efforts our INvestigationS In Gout, Hyperuricemia, and comorbidiTies 
(INSIGHT) Center of Research Translation (CORT) on 4 research projects. The Administrative Core will 
facilitate knowledge translation of our theme, “Gout, Hyperuricemia, and Associated Comorbidities” to 
researchers, clinicians, patients, trainees, and policy makers. The goal for the INSIGHT CORT is to improve 
the healthcare of patients and reduce the societal burden of gout and hyperuricemia by applying scientifically 
rigorous, state-of-the-art methodology to clinically important translational research questions. The 
Administrative Core aims to: 
 (1) Provide oversight management, methodologic, and statistical support for projects comprising the INSIGHT 
CORT; (2) Conduct outstanding, innovative research projects drawing on unique strengths of the major 
partners at University of Alabama at Birmingham (UAB), Harvard University Medical School-affiliated 
Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH), and University of 
California San Diego (UCSD), using state-of-the-art tools from rheumatology, genetics, statistics, 
epidemiology, and outcomes research; (3) Foster the development of pilot and feasibility projects and the 
development and application of new evaluative, analytic, and translational methods to research in gout and 
hyperuricemia; (4) Promote the training of clinical investigators in the most current methods of translational 
research and evaluation applicable to gout and hyperuricemia through an enrichment program; (5) Maintain 
and enlarge the UAB Gout Rheumatology, Arthritis Database and Repository, a resource that will serve CORT 
projects proposed in this application; (6) Coordinate interactions with the Advisory Committees. 
To achieve the overall goal of the INSIGHT CORT and to accomplish its objectives, the Administrative Core 
will provide day-to-day scientific oversight of the program. It will coordinate the CORT's activities while 
facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation 
of ongoing CORT programs, and setting the strategic agenda for the CORT.

## Key facts

- **NIH application ID:** 10263202
- **Project number:** 5P50AR060772-10
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Kenneth G Saag
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $326,696
- **Award type:** 5
- **Project period:** 2012-09-20 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263202

## Citation

> US National Institutes of Health, RePORTER application 10263202, Administrative Core (5P50AR060772-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10263202. Licensed CC0.

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