# Biostats Core (TBD)

> **NIH NIH P01** · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $312,636

## Abstract

PROJECT SUMMARY – BIOSTATISTICS AND BIOINFORMATICS CORE 3
The overarching goal of the P01 application “Molecular Targeted Radionuclide Therapy for Tumor
Immunomodulation and Enhancing Immunotherapy Response” is to develop a broad mechanistic understanding
of the immunomodulatory capacity of molecular targeted radionuclide therapy as part of the next generation of
immunotherapy approaches to improve the treatment of immunologically “hot” and “cold” tumors. The
overarching goal of the Biostatistics and Bioinformatics Core (BBC) is to promote excellence in pre-clinical
translation research proposed in this P01 application by providing dedicated and outstanding consultation and
collaborative support and expertise in biostatistics, bioinformatics and research data management for the P01
Projects 1-4, Administrative Core, Core 1 (Radionuclide Production and Radiochemistry Core), and Core 2
(Advanced Imaging and Dosimetry Core), and as needed.
The biostatistics component will provide support for all four projects and two cores. The biostatistics team draws
its strength from biostatistics faculty with many years of collaboration with the P01 investigators. Biostatistics
support for Project 1 and Core 2 (Advanced Imaging and Dosimetry Core) will be descriptive and exploratory in
nature and involve statistical modeling and estimation in dosimetry studies. Biostatistics support for Projects 2-
4 will involve statistical modeling and inference and will be comparative in nature.
The bioinformatics component proposes to provide support for Projects 2-4. The bioinformatics team draws its
strength from bioinformatics faculty who have active collaboration with the P01 investigators. More specifically,
it will provide bioinformatics support and analysis expertise with 1) T cell receptor sequence data, 2) RNAseq
data from selective tumors of mice that show curative eradication of tumors in comparison with control tumors
and to tumors receiving sub-optimal therapy resulting in escape of immunotherapy, and 3) single cell RNAseq
data.
In supporting the Administrative Core and the P01 overall, the BBC will develop a P01-wide database using a
relational database management system that will serve as the database of record for all projects and cores for
this P01. The BBC will provide support in research data management using this database, which will hold all
data generated from the Projects and Cores of the P01 and serve as the central data hub upon which all
biostatistics and bioinformatics analyses will be based.

## Key facts

- **NIH application ID:** 10263253
- **Project number:** 5P01CA250972-02
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** KyungMann Kim
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $312,636
- **Award type:** 5
- **Project period:** 2020-09-14 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263253

## Citation

> US National Institutes of Health, RePORTER application 10263253, Biostats Core (TBD) (5P01CA250972-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10263253. Licensed CC0.

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