# Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)

> **NIH NIH R01** · ADVENTHEALTH ORLANDO · 2021 · $803,485

## Abstract

Project Summary/Abstract
Targeted therapies for aging-related mobility disability are urgently needed to preserve quality of life and pre-
vent morbidity/mortality in the rapidly expanding aging population. Progressive decline in mobility with aging
has been partially attributed to loss of skeletal muscle (SM) mass and function, as well as an increase in the
quantity of adipose tissue (AT). The quality of AT and AT-secreted factors are also likely to influence this pro-
cess, yet meager evidence exists for this notion. Cellular senescence, a phenomenon by which normal healthy
cells cease to divide and therefore become programmed for cellular death, occurs in adipose tissue and is as-
sociated with poorer mobility. Furthermore, secreted factors from AT, potentially from senescent or dying cells,
induces insulin resistance and atrophy in human skeletal muscle cells. Collectively, these data demonstrate
that AT quality (i.e., structure and function) can directly impact skeletal muscle function. This adipose-skeletal
muscle crosstalk has been increasingly implicated in poor functional and metabolic outcomes in younger hu-
man populations. The unique contributions of AT structure and function and AT-secreted factors to mobility de-
cline and skeletal muscle function in the context of human aging have not been addressed. The proposed stud-
ies will fill a critical knowledge gap by directly assessing structural and functional components of AT in aging
and using their associations with mobility to identify AT-secreted proteins that negatively impact skeletal mus-
cle function. The long-term goal of this ancillary study is to leverage and add to the outstanding resources of
the parent SOMMA project to understand the contribution of AT quality, AT-secreted factors and AT-skeletal
muscle crosstalk to mobility disability and other complications of aging in humans. Our overall objective is to
identify key structural and functional components of AT quality - including necrosis, senescence, inflammation,
self-renewal and metabolic flexibility - and AT-secreted proteins that influence mobility via direct effects on
skeletal muscle. We hypothesize that AT structure and function influences AT-secreted proteins that contribute
to aging-related mobility outcomes by directly impacting skeletal muscle function. The stated purpose of Aim 1
is to determine which structural and functional components of AT are associated with slower walking speed.
We posit that increased cellular senescence, increased necrosis, increased inflammation, decreased capacity
for self-renewal and metabolic inflexibility will be associated with slower walking speed. For Aim 2, we antici-
pate that incubation of human muscle cells with known and novel secreted proteins - identified through stand-
ard immunoassay panels and unbiased proteomics and shown to be associated with aberrations in AT struc-
ture and/or function - will worsen mitochondrial respiration, increase oxidative stress, decrease c...

## Key facts

- **NIH application ID:** 10263254
- **Project number:** 5R01AG066474-02
- **Recipient organization:** ADVENTHEALTH ORLANDO
- **Principal Investigator:** ERIN E. KERSHAW
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $803,485
- **Award type:** 5
- **Project period:** 2020-09-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263254

## Citation

> US National Institutes of Health, RePORTER application 10263254, Investigating the role of adipose tissue in mobility and aging (SOMMA-AT) (5R01AG066474-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10263254. Licensed CC0.

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