# Neuropathology Core

> **NIH NIH P30** · DUKE UNIVERSITY · 2021 · $286,334

## Abstract

ABSTRACT – NEUROPATHOLOGY CORE
The Neuropathology Core serves a critical role in the Duke/UNC Alzheimer’s Disease Research Center (ADRC)
given the neuropathological assessment needed for a definitive Alzheimer’s disease (AD) diagnosis and the
demand for brain and other tissue from individuals whose behavioral, clinical, and biological trajectories were
well-documented prior to death. The Core supports research and innovations across the Duke/UNC ADRC
research community, by performing postmortem histopathological analysis and providing well-annotated and
high-quality postmortem tissue and biofluids to investigators studying AD and Alzheimer’s disease-related
dementias (AD+ADRD). Building on strong infrastructure at Duke and UNC, the Core proposes the following
Specific Aims: 1) Collect, store, and distribute unique and high-quality postmortem blood, CSF, brain, and eye
tissue. 2) Facilitate cutting-edge omics studies of AD. 3) Provide neuropathology diagnostic support. 4) Track
and report neuropathology data and specimen distribution. 5) Provide diagnostic training and scientific leadership
to investigators utilizing Core resources for research. The Core’s combination of state-of-the-art diagnostic
procedures, collection of high-quality postmortem tissue, and expertise in diagnostic training will enable the
creation and expansion of high-impact research initiatives across the ADRC aimed at the identification of age-
related drivers of AD.
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## Key facts

- **NIH application ID:** 10263687
- **Project number:** 1P30AG072958-01
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** SHIH-HSIU Jerry Wang
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $286,334
- **Award type:** 1
- **Project period:** 2021-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263687

## Citation

> US National Institutes of Health, RePORTER application 10263687, Neuropathology Core (1P30AG072958-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10263687. Licensed CC0.

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