# Core 3: Rexinoid Screening and Animal Core

> **NIH NIH P01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2021 · $186,229

## Abstract

The Rexinoid Screening and Animal Core (Animal Core) is a critical component of the Program
Project Grant. It supports the goals and objectives of the Program by providing pre-clinical
efficacy and safety information on novel rexinoids, designed by Project 2, that have the potential
to be useful as chemopreventive agents for non-melanoma skin cancers in organ transplant
recipients. Effective dose 50 (ED50) for prevention of non-melanoma skin cancer in normal and
cyclosporine-treated mice will be established for each candidate rexinoid; the ED50 of our
current lead compound, UAB30, which will be used as a comparator. Pharmacokinetics,
tolerability, organ toxicity and lipid abnormalities of the newly synthesized rexinoids will also be
determined. Another service provided by the Rexinoid Screening and Animal Core is to
maintain a colony of Ptch+/-/SKH1 mice. Following chronic exposure to UV radiation, these mice
develop basal cell carcinomas, squamous cell carcinomas and premalignant actinic keratoses.
Thus, they carefully replicate human skin cancer susceptibility to UV. Maintaining a breeding
colony of these unique mice will be particularly important for the experiments proposed in
Projects 2 and Project 3. Tissues from these mice will also be banked and made available for
analysis to Program investigators. Core scientists will also provide assistance in development
of experimental protocols, IACUC approvals, and help with UV irradiation and
immunosuppression protocols.

## Key facts

- **NIH application ID:** 10263928
- **Project number:** 5P01CA210946-05
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Mohammad Athar
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $186,229
- **Award type:** 5
- **Project period:** 2017-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10263928

## Citation

> US National Institutes of Health, RePORTER application 10263928, Core 3: Rexinoid Screening and Animal Core (5P01CA210946-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10263928. Licensed CC0.

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