# Arizona Alzheimer's Disease Research Center

> **NIH NIH P30** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2021 · $3,217,035

## Abstract

OVERALL — PROJECT SUMMARY/ABSTRACT
Over the last 20 years, Arizona researchers established NIA's first statewide Alzheimer's Disease Center and
the nation's most extensive statewide collaboration in Alzheimer's disease (AD) research. They made pioneering
contributions to the unusually early detection, tracking and study of AD and the accelerated evaluation of AD
prevention therapies. The Center includes researchers from seven organizations, six in the Phoenix metropolitan
area and one in Tucson. It has supported 150 researchers from organizations across the state and helping them
to generate more than $2 billion in new grants, contracts, philanthropic, state and organizational investments.
The Arizona AD Research Center (ADRC) will capitalize on the Center's leadership, statewide collaborative
model, major organizational commitments, and extensively shared scientific resources and its very existence to
make the scientific fight against AD a top priority in the state. Its resources, strategic plan, and related programs
and prevention trials are specifically intended to set the stage for promising blood tests to transform AD/ADRD
research, treatment development, and care, include persons from diverse backgrounds, find an effective
prevention therapy by 2025, and fulfill National Alzheimer's Project Act (NAPA) goals. We will use ADRC,
organizational and philanthropic funds to provide an extraordinary resource of data and blood samples for
neuropathological study and diagnostic validation of BBBs for ADRD using blood samples from several hundred
brain donors in the last years of life who have comprehensive neuropathological assessments after they die. The
overall goals of the Center will be accomplished through coordinated activities of its six Cores and the Research
Education Component (REC). The Administrative Core will provide the scientific leadership to the ADRC as a
whole. The multi-site Clinical Core will perform standard evaluations and collect UDS and additional data on all
participants, including a large number of Hispanic/Latino and Native American participants. The Neuropathology
Core will provide neuropathologic diagnoses and process, store and distribute postmortem brain tissue, including
from those who provided blood samples in the last 1-2 years of their lives. The Biomarker Core will support and
provide access to genetics, brain imaging (MRI, amyloid PET, tau PET), cerebrospinal fluid (CSF) and BBBs of
AD. The Outreach, Recruitment and Engagement (ORE) Core will support the efforts of the Clinical and
Neuropathology Core, providing a range of educational and outreach programs for healthy adults, patients and
family caregivers in our Center's catchment area, including from Arizona's large Hispanic/Latino and Native
American communities. The Data Management and Statistics Core will support all the data management,
informatics and statistical needs of the Cores and Center. The REC will coordinate closely with each of the Cores
and lever...

## Key facts

- **NIH application ID:** 10264187
- **Project number:** 1P30AG072980-01
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** ERIC MICHAEL REIMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $3,217,035
- **Award type:** 1
- **Project period:** 2021-09-05 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264187

## Citation

> US National Institutes of Health, RePORTER application 10264187, Arizona Alzheimer's Disease Research Center (1P30AG072980-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10264187. Licensed CC0.

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