# Core D: Neuropathology Core

> **NIH NIH P30** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2021 · $293,115

## Abstract

PROJECT SUMMARY/ABSTRACT – NEUROPATHOLOGY CORE
 The Neuropathology Core is an essential part of the Alzheimer's Disease Core Center (ADRC). During life,
the signs and symptoms of Alzheimer's disease (AD) are not sufficiently different from several other conditions,
resulting in misdiagnosis, even at the most advanced centers, in 25% or more of subjects, when newly developed
imaging and biofluids biomarkers are not used. Even with such biomarkers, the presence of concurrent and
clinically significant major pathologies is rarely detected. Examination of the brain after death by an experienced
Neuropathologist allows the Center's research results to be appropriately interpreted. This is particularly
important for our Center's overarching theme, to provide the resources needed to establish the accuracy of
emerging blood-based biomarkers (BBBs) in the diagnosis of AD and related dementias (ADRD) and use them
to detect, track, and study preclinical AD, including in persons from diverse backgrounds, and to find an effective
AD prevention therapy by 2025. A second major role of the Neuropathology Core is to provide an extensive
resource of rapidly autopsied, neuropathologically and molecularly characterized tissue for researchers inside
and outside of Arizona, enabling them to discover the underlying molecular mechanisms of disease and design
appropriate therapeutic interventions. A detailed understanding of the genomics and related molecular processes
of disease pathogenesis, obtained by comparative study of diseased and non-diseased brain tissue is critical to
finding such interventions. A third important goal of the Neuropathology Core is to support the Arizona ADRC's
overarching theme and address National Alzheimer's Project Act (NAPA) Implementation Milestones. Our
Specific Aims: 1) To provide comprehensive neuropathological assessments and extremely precise
neuropathologic diagnoses in ADRC Clinical Core and Affiliated Brain and Body Donation Program (BBDP)
research participants who donate their brains after they die. 2) To provide an extensively shared resource of
rapidly autopsied, high-quality neuropathologically characterized brain tissue and other body tissues for
researchers to advance the study of AD/ADRD, support the study of molecular mechanisms, and therapeutic
targets, including in those with AD and a wide range of ADRDs as well as cognitively unimpaired persons with
and without preclinical AD. 3) To provide an extensively shared resource of ADRC and organizationally
supported annual blood samples, neuropathological diagnoses, and data to help researchers inside and outside
of Arizona evaluate promising BBBs for AD/ADRD in neuropathologically characterized brain donors by providing
neuropathological validation of blood samples acquired in the last 1-2 years of life. The last aim is intended to
support the role of BBBs in the diagnosis and preclinical detection, tracking and study of AD, the inclusion of
under-represented Hispanic/Latino,...

## Key facts

- **NIH application ID:** 10264191
- **Project number:** 1P30AG072980-01
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** THOMAS G BEACH
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $293,115
- **Award type:** 1
- **Project period:** 2021-09-05 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264191

## Citation

> US National Institutes of Health, RePORTER application 10264191, Core D: Neuropathology Core (1P30AG072980-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10264191. Licensed CC0.

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