# Core F: Biomarker Core

> **NIH NIH P30** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2021 · $973,609

## Abstract

PROJECT SUMMARY/ABSTRACT - BIOMARKER CORE
The Biomarker Core (BC) will provide access across the Arizona ADRC to advance brain imaging, fluid, and
wearable/digital biomarker expertise, resources, data, and specimens for application with our center and
complementary affiliated cohorts to support NIA ADRC program goals. The Arizona ADRC has a major
thematic focus on advancing efforts in the use of blood-based biomarkers (BBBs) in the diagnosis, preclinical
study and prevention of AD. The BC will facilitate this thematic focus by supporting ADRC researchers in their
efforts to: 1) further clarify the cognitive and biological changes associated with preclinical AD; 2) validate and
clarify the role of new brain imaging, CSF, and blood-based biomarkers in the early detection and tracking of
AD and to evaluate the potential of wearable/digital technologies as behavioral AD biomarkers; 3) inform the
design, endpoints, and statistical power of prevention trials in individuals at different levels of AD risk to support
our goal of finding effective AD prevention therapies; and 4) provide a valuable shared resource for Arizona
ADRC researchers, the NIA ADRC program nationally, and researchers around the world studying AD and
related disorders. To achieve these goals, the BC will support the standardized acquisition, processing, and
analysis of amyloid PET, tau PET, and MRI; the standardized collection, preparation, storage, and analysis of
blood, CSF, and DNA samples; and the acquisition, processing, and analysis of wearable/digital behavioral
biomarkers in clinically well-characterized ADRC participants, many of whom have also agreed to brain
donation. The BC will maintain a strong relationship with NCRAD for the processing and banking of blood and
CSF samples and will fully support the NIA SCAN initiative for the sharing and archiving of ADRC BC
neuroimaging scans with NACC. The BC will provide expertise and support to help ADRC researchers fully
utilize the core resources and will work with each of the Arizona ADRC Cores, as well as investigators within
and outside Arizona, to advance AD-related research. The BC will address the following specific aims: 1) to
provide access to amyloid and tau PET, MRI scans, CSF and blood samples, and wearable/digital activity data
across the Arizona ADRC; 2) to make available for research neuroimaging data, fluid specimens and
biomarkers, and wearable/digital activity data from clinically well-characterized ADRC participants; 3) to
support the development, evaluation, and implementation of blood-based biomarkers for early detection and
tracking of AD risk and pathology; 4) to provide a resource of expertise and support for brain image processing
and analysis for use in AD-related research studies; and 5) to foster collaborative research by working closely
with each of the Arizona ADRC Cores, as well as users of these core resources inside and outside Arizona.

## Key facts

- **NIH application ID:** 10264193
- **Project number:** 1P30AG072980-01
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** GENE E ALEXANDER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $973,609
- **Award type:** 1
- **Project period:** 2021-09-05 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264193

## Citation

> US National Institutes of Health, RePORTER application 10264193, Core F: Biomarker Core (1P30AG072980-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10264193. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*