# Core G: Genetics and Molecular Profiling

> **NIH NIH P30** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $452,798

## Abstract

Many recent advances in genetics and genomics technologies and rapid growth in knowledge of genetic risk
factors for Alzheimer disease (AD) reinforce the importance of and opportunities for incorporating genetic
information and designs into AD research. The Genetics & Molecular Profiling (GMP) Core will support genetics
and `omics research by ADRC investigators, trainees and established investigators who are “breaking in” to AD
research, and to build foundations for translational studies using ADRC resources. Given the centrality of
genetics and `omics data to diverse scientific areas, unrealistic expectations that most AD researchers are
capable and can afford to generate such data, and importance of avoiding costly duplicative data generation in
order to preserve limited and precious specimen resources, the GMP Core will generate an array of genetic and
`omic data. Although the GMP Core is a new component of the ADRC, it will build on our work of genetic and
molecular characterization of BU ADC participants and other cohorts that has led to numerous important
discoveries and greatly increased our understanding of mechanisms and biological pathways leading to AD. We
will continue to serve as a centralized resource for the organization and analysis of genetic data within the ADRC
and ADRC affiliated projects by providing an infrastructure needed to coordinate molecular research efforts that
will lead to a better understanding of genotype-phenotype relationships for dementia and related
endophenotypes. Specifically, the GMP Core will (1) process, extract DNA and RNA, store and distribute genetic
material extracted from biological specimens (e.g., blood, brain, saliva) obtained from ADRC participants; (2)
generate genome-wide array, DNA and RNA sequence, epigenetic and lipidomic data for use by ADRC and
other BU investigators, as well as the scientific community; (3) track the collection and usage of genetic material;
(4) manage all genetic and `omic data in collaboration with the Data Management & Statistics (DMS) Core; (5)
maintain an integrated genetic and `omic database includes all genetic and `omic data generated from BU ADRC
samples, as well as working libraries of extant genetic and `omic data; these data will be available with proper
permissions as a resource for genetic analyses with guidance from the core investigators. The GMP Core will
also facilitate access to an extensive set of genetic and genomic data from extant datasets that are available to
the Core investigators including individual level and/or summarized data from the ADGC, ADSP, ADNI, AMP-
AD, and UK Biobank; and (5) provide support for designing genetic and genomic studies, as well as for data
analysis. In line with our vision for precision medicine, this profiling integrated with the extensive characterization
performed in the Clinical, Biomarker and Neuropathology Cores will facilitate both agnostic and hypothesis-
driven research. The Core will also partner with existing...

## Key facts

- **NIH application ID:** 10264294
- **Project number:** 1P30AG072978-01
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** Lindsay A. Farrer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $452,798
- **Award type:** 1
- **Project period:** 2021-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264294

## Citation

> US National Institutes of Health, RePORTER application 10264294, Core G: Genetics and Molecular Profiling (1P30AG072978-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10264294. Licensed CC0.

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