# NORTHWESTERN Alzheimer's Disease Research Center

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2021 · $3,319,145

## Abstract

PROJECT SUMMARY - OVERALL COMPONENT
The Northwestern ADRC is in its 25th year. This renewal application describes the progress of the past cycle
and a plan of action for the next 5 years, during which we will pursue the following principal goals:
 1) Support innovative research at Northwestern University on the biology, early diagnosis, risk factors, and
 treatment of dementias by bringing together basic and clinical investigators.
 2) Participate in national collaborations that leverage the strengths of the NIA Centers by using the UDS-3
 and FTLD Module and transmitting data to NACC, and participating in ADNI, ADCS, NCRAD, LOAD,
 ADGC, and FTLD-related consortia.
 3) Serve a leadership role in FTLD neuropathology, primary progressive aphasia (PPA), dementias
 associated with TDP-43 pathology, mid-life onset AD (MOAD), microglia and neuroinflammation, and
 unusually successful brain aging (SuperAging) in keeping with the unique strengths of the Northwestern
 ADRC in this area of aging and dementia research.
 4) Train fellows and junior faculty and attract new investigators to dementia research through accredited
 clinical fellowships, Development Project awards, and training grants.
 5) Ensure that patients, families, and underserved populations are beneficiaries of relevant advances
 through education, outreach, and novel life enrichment programs.
The cores of the ADRC are configured to serve the specific goals listed above. The Administrative Core will be
responsible for the clinical, scientific and fiscal leadership of the entire ADRC, as well as the coordination with
national consortia and the selection of Development Projects. The Clinical Core will maintain a cohort of well-
characterized subjects recruited to address ongoing research priorities. The Data Management and Statistics
Core will ensure that the data are stored in ways that maximize collaboration and that biostatistical consultation
plays a key role in the design and interpretation of research. The Neuropathology Core will characterize
patients who come to autopsy according to up-to-date criteria, and distribute tissue, slides, DNA, and data for
local and national collaborations. The Outreach, Recruitment and Engagement Core will work with the Clinical
Core to enhance participant recruitment and retention in the ADRC, and will develop innovative life enrichment
programs to serve patients and their families. The Research Education Component will oversee diversity
recruitment for researchers and junior faculty and coordinate training requirements for the Responsible
Conduct of Research. The Imaging Biomarker Core will perform up-to-date multimodal neuroimaging of Clinical
Core participants, including amyloid and tau PET. The Executive Committee, composed of all key personnel,
will formulate ADRC priorities based on local and national mandates and will review requests for patients,
controls, tissue, and data.

## Key facts

- **NIH application ID:** 10264367
- **Project number:** 1P30AG072977-01
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** ROBERT J VASSAR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $3,319,145
- **Award type:** 1
- **Project period:** 2021-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264367

## Citation

> US National Institutes of Health, RePORTER application 10264367, NORTHWESTERN Alzheimer's Disease Research Center (1P30AG072977-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10264367. Licensed CC0.

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