# Core D - Biostatistics/Bioinformatics

> **NIH NIH P50** · UNIVERSITY OF IOWA · 2020 · $260,224

## Abstract

The Biostatistics and Bioinformatics Core provides integrative statistical and informatics support to the Iowa 
Neuroendocrine Tumor (NET) SPORE. This support is provided to the SPORE: projects, developmental 
projects and associated cores. The comprehensive nature of the Core encompasses basic, translational, and 
clinical projects, assuring each SPORE investigator access to expertise that includes development of study 
designs, state of the art data analysis and interpretation, data management resources, abstract and manuscript 
preparation, and synergistic interaction with all other core components through gate keeping and analyses 
information sharing. The Core builds upon the innovative procedures and systems in the University of Iowa 
Holden Comprehensive Cancer Center, the Department of Biostatistics in the College of Public Health and the 
Coordinated Laboratory for Computational Genomics in the School of Engineering. Design and analysis 
support has been and will be provided across a range of fields, including basic chemistry and pharmacology, 
exome sequencing and mutation discovery, expression analysis, imaging pharmacokinetics and dosimety, 
clinical trials, and population science. The Core designed, developed, and will continue to upgrade the Iowa 
Neuroendocrine Tumor Database. Support is also provided for the management and integration of existing and 
newly collected data through consistent and compatible genomic data handling. Additional areas of support for 
clinical trials include data form development and processing, data collection and entry, data archiving, quality 
control, and data safety monitoring. In addition to being actively involved with the preparation of statistical 
plans for the four projects in this application, the Core was also involved in the management of information 
pertaining to Exome sequencing, gene mutation identification and analysis of G-protein coupled receptor 
expression. The Core has and will continue to provide statistical experimental design, data analysis and 
management for all studies, and preparation of data summaries for manuscript publication. In summary, 
strengths of the Biostatistics and Bioinformatics Core are complete integration into, and synergistic interaction 
with, each of the SPORE projects and associated cores, the unique Iowa Neuroendocrine Tumor Database 
incorporating both genotypic and phenotypic information, and the breadth of expertise provided by the 
Biostatistics and Bioinformatics personnel.

## Key facts

- **NIH application ID:** 10264526
- **Project number:** 3P50CA174521-05S2
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** GIDEON D ZAMBA
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $260,224
- **Award type:** 3
- **Project period:** 2015-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10264526

## Citation

> US National Institutes of Health, RePORTER application 10264526, Core D - Biostatistics/Bioinformatics (3P50CA174521-05S2). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10264526. Licensed CC0.

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