Project Summary/Abstract The Stanford Clinical Center applies to participate in the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC), to contribute its established clinical and research infrastructure in acute pancreatitis and expertise in pancreatology, endocrinology, and immunology. Our group is well- positioned to develop a prospective cohort of patients with acute pancreatitis to support human based studies investigating the relationship of diabetes, with a particular focus in Type 1 diabetes mellitus (T1D), in acute pancreatitis. In response to the research objectives of the T1DAPC as outlined in this RFA, we have formed a strong complementary scientific team. Our proposal is highly responsive to the RFA in several specific ways. The Stanford Clinical Center has the capacity and infrastructure to effectively recruit patients into this prospective cohort of acute pancreatitis patients. Second, We propose to use prospectively collected bio-specimens from this cohort to examine the role of the immune system in acute pancreatitis and its relationship to the development of diabetes. Third, we propose to look at hormonal changes associated with post-pancreatitis diabetes (PPDM) as well as the potential relationship between PPDM and exocrine pancreatic insufficiency. The opportunity to pursue these investigations in collaboration with other centers as a Consortium is an exciting novel opportunity to study acute pancreatitis and its relationship with type 1 diabetes.