# The MRN complex in Lymphocyte Development and Genome Stability

> **NIH NIH R56** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $608,512

## Abstract

Abstract
 Cellular responses to DNA double strand breaks require rapid communication between
specialized DNA damage recognition complexes and the core cell cycle machinery, but this
important relationship is poorly understood. Mre11, a core component of the DNA damage
recognition machinery that is mutated in ataxia-telangiectasia like disorders (ATLD), has been
shown to interact with cyclin dependent kinase 2 (CDK2), a core component of the cell cycle
machinery.
 In this proposal we will test the overarching hypothesis that Mre11 interacts with and controls
CDK2 to provide a rapid switch between the normal cell cycle and the DNA damage response.
We will determine roles that Mre11-CDK2 interaction plays in diverse biological contexts such
as specialized DNA recombination in lymphocyte development, and S phase checkpoint
responses more generally. The studies proposed herein take advantage of previously
constructed murine systems, along with new mouse lines that model human ataxia
telangiectasia-like disorder. Collectively, the proposed studies will significantly contribute to our
understanding of cellular responses to DNA damage and their associated diseases.

## Key facts

- **NIH application ID:** 10266210
- **Project number:** 1R56HL153068-01
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DAVID O FERGUSON
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $608,512
- **Award type:** 1
- **Project period:** 2020-09-23 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10266210

## Citation

> US National Institutes of Health, RePORTER application 10266210, The MRN complex in Lymphocyte Development and Genome Stability (1R56HL153068-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10266210. Licensed CC0.

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