SUMMARY The Biospecimen Core B is designed to support all aspects of this SPORE grant that need to use or analyze biospecimens. We have 4 specific aims that are designed to span the needs of the projects and include potential future work, including the DRPs and CDPs. Our aims include: Aim 1: To collect, store and distribute human biospecimens with complete clinical, pathological, and demographic annotation. Aim 2: To conduct or assist in the collection, maintenance and distribution of HNSCC cell lines. Aim 3: To conduct or assist in preparation for genomic analyses of biospecimens. And, Aim 4: To conduct or assist in the in situ molecular pathology analyses of biospecimens. In the body of the proposal we expand on our capacities and preliminary data for each aim. We also illustrate how the core will meet the needs of the relevant specific aims of each project. Overall, we look forward to being a key tissue provider and analysis facility to allow the SPORE project to seamlessly generate data from the Yale and Fox Chase Cancer Center tissue resources.