# Automated control of artificial lung systems to meet patient metabolic needs

> **NIH VA I01** · VETERANS HEALTH ADMINISTRATION · 2021 · —

## Abstract

Tens of thousands of Americans and Veterans with end stage lung disease (ESLD) are not candidates for lung
transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and
eventually total respiratory failure. The long-term goal of this technology-development project is to improve
rehabilitation from lung disease by developing artificial lung systems that automatically and rapidly
compensate for the changing respiratory and metabolic needs of the patient, thereby increasing patient health,
comfort, activity, and ability to exercise and rehabilitate. The objectives of the current proposal are to: 1)
develop a control system for an artificial lung system featuring sweep gas servoregulation to adjust CO2
removal based on patient need; and, 2) evaluate the control system in animal models. At the completion of this
project, we expect to be ready to integrate the developed control system with various artificial lung systems
and prostheses that will, for the first time, enable large changes in patient activity during rehabilitation and daily
life.

## Key facts

- **NIH application ID:** 10268182
- **Project number:** 5I01RX003114-03
- **Recipient organization:** VETERANS HEALTH ADMINISTRATION
- **Principal Investigator:** Joseph Allen Potkay
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2019-11-01 → 2023-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10268182

## Citation

> US National Institutes of Health, RePORTER application 10268182, Automated control of artificial lung systems to meet patient metabolic needs (5I01RX003114-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10268182. Licensed CC0.

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