# Catheter Based Cardiovascular Device Retrieval System

> **NIH NIH R42** · ONOCOR, LLC · 2021 · $1,708,264

## Abstract

Recent advances in technology have made possible the treatment of a growing number of
structural cardiovascular diseases by catheter based procedures. Atrial septal defects (ASD),
ventricular septal defects (VSD), aortic aneurysm, congenital defects and valve disease are all
currently being treated with catheter based strategies. These procedures are complex and are
prone to device misplacement, even by experienced operators. Currently remedial surgical
procedures are required to retrieve misplaced devices. A transcatheter retrieval system would
represent a major advance that would spare patients the pain of remedial surgical procedures
and provide a “safety net” that promotes the use of these less invasive procedures and expands
the number of patients who benefit from them. Onocor has begun development of such retrieval
system. The Onocor system consists of (1) customized co-axial catheter for introduction of the
system and recovery of the target implant, (2) a novel nitinol wire woven basket designed to
envelope, compress and retrieve the target implant, (3) mechanical advantage system for
steady application of the withdraw force and (4) manipulation tools to aid in orienting the target
implant.
In preliminary work, carried out in Phase I, we have demonstrated the effectiveness of the
basket in compressing large stents (aortic valve frames, aortic aneurysm stents). The efficacy of
the retrieval system in removing many types of misplaced cardiovascular devices has also been
extensively demonstrated in animal models. The goal of the current Phase II STTR proposal
is to refine the design concept to the point of first-in-man applications

## Key facts

- **NIH application ID:** 10268993
- **Project number:** 5R42HL139309-03
- **Recipient organization:** ONOCOR, LLC
- **Principal Investigator:** JOSEPH H GORMAN
- **Activity code:** R42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,708,264
- **Award type:** 5
- **Project period:** 2018-09-24 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10268993

## Citation

> US National Institutes of Health, RePORTER application 10268993, Catheter Based Cardiovascular Device Retrieval System (5R42HL139309-03). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10268993. Licensed CC0.

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