This application is for a 5-year renewal (Years 39-43) of the Training Program in Cancer Epidemiology, Prevention, and Control (T32 CA009314) at the Johns Hopkins Bloomberg School of Public Health. Our mission is to train pre- and postdoctoral trainees to be leaders at the forefront of advancing knowledge of a) causes of cancer, including inherent and modifiable factors in human populations locally, nationally, and globally; b) how to prevent and reduce cancer burden locally, nationally, and globally by i) providing and communicating a better understanding of behaviors that influence cancer development and promote healthy survivorship, ii) identifying new markers for early detection of cancer, and iii) identifying and addressing cancer disparities including in vulnerable populations and barriers to care; and c) how to translate, implement, and evaluate cancer epidemiology, prevention, and control discoveries into populations. We provide a rich and interactive environment augmented by highly innovative, productive, and collaborative cancer research conducted at the Schools of Public Health and Medicine and Sidney Kimmel Comprehensive Cancer Center. The Training Program provides cancer-relevant methodologic and cancer-specific substantive area research training. 6 pre- and 2 postdoctoral trainees pursue tailored curricula with shared elements: didactic courses on substantive and methodologic topics, responsible conduct of research, research rigor, reproducibility, and transparency; interactive information exchange; teaching, communication, grant writing; community outreach and engagement experience; mentored pre- or postdoctoral research; and cancer-specific professional development. We stress developing and testing novel hypotheses and collaborating across disciplines. Via shared elements, trainees are exposed to contemporary cancer topics such as molecular epidemiology, big data, social justice and disparities, aging, HIV, personalized risk assessment, screening, survivorship, implementation, communication, policy. 26 Preceptors (23% underrepresented groups, 77% identify as women), selected for outstanding mentoring and cancer-relevant research records, are primary mentors. With the Director, the Executive Committee is responsible for trainee selection/monitoring, and program refinement as cancer research evolves. Internal and External Advisory Committees provide evaluation and advice. Training duration is 4 years for pre- and 2-3 years for postdoctoral trainees. We have a strong record: 43 pre- and 25 postdoctoral trainees in the last 15 years completed or are in training. They have had career success (89.2% research or related). From a large pool of applicants, the best candidates are recruited. 20% are from underrepresented groups. In summary, the Program is designed to a) provide trainees with a multidisciplinary background essential to conduct highest caliber, state-of-the-art, collaborative, population-based foundational or applied cancer r...