ABSTRACT: ADMINISTRATIVE CORE The overarching goal of the Administrative Core is to provide the operational support necessary to successfully achieve the goals we have laid out for each project and our program as a whole. The Administrative Core will serve as a central forum for communication, planning, and common administrative and financial management among the projects and cores. We will maximize efficiency, cost-effectiveness, and productivity by centralizing resources used by each of the projects and cores. The Administrative Core will be led by Dr. Kari Nadeau and will involve the Project and Core leaders and National Heart, Lung, and Blood Institute (NHLBI) Program Staff on a Steering Committee. Day-to-day operations of the Administrative Core will be overseen by a full-time Program Manager. The Administrative Core has the following specific aims: Aim 1. provide operational oversight and integration of projects and cores across the proposed program, Aim 2. provide processes and procedures for the fiscal administration of the PPG, Aim 3. convene internal and external advisory board meetings and facilitate meaningful interactions between advisory boards and PPG members, Aim 4. monitor project productivity and assess use of core resources and Aim 5. broadly disseminate results. Overall, the Administrative Core will provide fully integrated administrative services for the management, communications, coordination, and financial administration of our PPG. In doing so, the Administrative Core will support the overall PPG in transforming our understanding of inflammation-associated cardiopulmonary pathology. The Administrative Core will provide centralized resources to each project and core, eliminating redundancy and enabling high-impact research.