# Penn TMC: Data Analysis Core

> **NIH NIH U54** · UNIVERSITY OF PENNSYLVANIA · 2021 · $193,682

## Abstract

The proper curation of data and processes for a large-scale public resource generation project is critical
to the success of projects like the HuBMAP TMCs. The goal of the Data Analysis Core is to support the
resource generation operations of the Penn Center for Multiscale Molecular Map of the Female
Reproductive System with data coordination. We will provide computational infrastructure to process all
data, implement Quality Control (QC) procedures, and enable data provenance. We will develop
metadata and provenance models of the clinical procedures, molecular procedures, and informatics
procedures. We will also develop QC methods for all processes and implement automatic systems for
QC checks. We will process all primary data, such as sequencing and image data, and prepare the data
for deposition to HuBMAP HIVE groups and other public repositories. We will also provide analyses for
the Center, including multi-modal integration and spatial integration. We will carry out data normalization,
batch correction, alignments between datasets and across scales, as well as integration of multi-modal
data types. We will develop a 3D digital model of the female reproductive system and use the model to
guide spatial indexing of the samples as well as to align the molecular data to their spatial contexts. We
will provide additional analytics specific to the project such as reconstructing periodic temporal dynamics.
Finally, we will coordinate with HIVE to deposit and disseminate data, programs and analysis outputs,
and material reagents. We will work with the HuBMAP HIVE groups to transform and QC the data to the
standards of the consortium and deposit the data with the consortium. We will also work with the
consortium to develop metadata standards, controlled vocabularies, ontologies, and other community
standards. We will also document all protocols, reagents, tissue biobanks, programs, and analysis
pipelines with data models and provide a public database for all associated information of the Penn
Center.

## Key facts

- **NIH application ID:** 10269927
- **Project number:** 5U54HD104392-02
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Alison Marie Pouch
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $193,682
- **Award type:** 5
- **Project period:** 2020-09-24 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10269927

## Citation

> US National Institutes of Health, RePORTER application 10269927, Penn TMC: Data Analysis Core (5U54HD104392-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10269927. Licensed CC0.

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