# Biostatistics

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2021 · $62,380

## Abstract

Project Summary/Abstract
The purpose of Core 4 Biostatistics is to provide statistical support to all the Projects in this P01. For the
association between clinical outcome and the comprehensive molecular and proteomic dissection of Richter's
syndrome (RS), as performed by Project 1, the Core will assemble and curate the clinical data provided by
internal and external collaborators and perform all analyses of association between these novel findings and
appropriate clinical parameters. This will include working closely with Project to assess in cfDNA any RS-specific
alternations that may predict this transformation. For all laboratory and animal studies of Projects 2 and 3, the
Core will assure that the design, conduct, and analysis of experiments use robust statistical techniques that are
appropriately implemented. For Project 2 this includes the single cell analyses of the tumor-intrinsic and tumor-
extrinsic features, as well as the longitudinal assessment of these features. The mice developing RS with
combinations of common CLL mutations (generated through this P01) will be assessed for response and
resistance to novel therapies and analyzed by this Core. DBP studies are performed through Project 3, and the
use of the Core for clinical association will permit Project 3 to remain blinded to clinical outcomes when
performing their assays, assuring an unbiased assessment of their predictive ability. Through these aims, this
central resource for the Projects will coordinate our insights into the trajectories from CLL to RS and support our
ability to identify rational and personalized therapeutic strategies that will offer patients an improved chance of
cure.

## Key facts

- **NIH application ID:** 10270044
- **Project number:** 2P01CA206978-06
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** DONNA S. NEUBERG
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $62,380
- **Award type:** 2
- **Project period:** 2016-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10270044

## Citation

> US National Institutes of Health, RePORTER application 10270044, Biostatistics (2P01CA206978-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10270044. Licensed CC0.

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