DEVELOPMENTAL FUNDS – PROJECT SUMMARY/ABSTRACT The Cold Spring Harbor Laboratory (CSHL) Cancer Center is marked by creative and energetic faculty, innovative and collaborative research, and an emphasis on developing technologies that are used broadly in cancer research labs around the world. Cancer Center Developmental Funds have provided critical seed funding to strategically recruit six new faculty, stimulated collaboration and interdisciplinary science through twelve pilot projects, and spurred innovation through the Shared Resources in eight technology-development projects. With the support of the Executive Committee and Senior Leadership, the Cancer Center Director utilized these funds to implement the Center’s strategic initiatives. When paired with substantial Institutional support and philanthropic funding, these Developmental Funds resulted in significant returns on investment, including 48 published papers and preprints and nine additional papers in preparation or under review. In addition, funding for new investigators led to data that supported the successful application for more than $5.7 million in peer- reviewed external funding and a total of 25 successfully funded external grants over the last five years. As a whole, Developmental Funds are an extremely valuable source of support that enables the CSHL Cancer Center to make fundamental discoveries about the biological mechanisms underlying cancer and to develop unique approaches towards the diagnosis, treatment, and prevention of cancer.