ANIMAL & TISSUE IMAGING SHARED RESOURCE – PROJECT SUMMARY/ABSTRACT This Shared Resource provides histology services for the characterization of murine and human tumor tissue and the evaluation of animal pathology. The samples submitted for analysis are analyzed with the latest technology and to the highest quality standards. Moreover, Cancer Center members have access to instrumentation for non-invasive ultrasound, bioluminescence, and fluorescence imaging to advance the molecular and physiological understanding of cancer biology. Furthermore, the exceptional expertise of the Shared Resource staff allows collaborative development of innovative approaches to highly specific and sensitive in vivo imaging using PET/CT and SPECT/CT instruments. These novel methods have particular application in assessing tumor response to experimental treatment, and to help develop and characterize novel diagnostic or therapeutic approaches. Overall, the goal of this Shared Resource is to provide support that leads to a deeper mechanistic understanding of cancer biology, and also to greatly advance the evaluation and characterization of cancer animal models at the CSHL Cancer Center. This Shared Resource is led by Faculty Head Lloyd Trotman, Ph.D., Director Scott Lyons, Ph.D, and Manager Qing Gao, Ph.D. In the last five-year period, this Shared Resource was used by 21 Cancer Center members (55% of members), and resulted in 40 publications or preprints.