Core 2. Biostatistics and Bioinformatics Abstract The Biostatistics and Bioinformatics Core of the MSCP SPORE provides services for the design of experiments and the analysis of in vitro, in vivo, clinical, translational and -omics data. The investigators and staff of both segments of the Core have significant experience in research in skin cancers, so that data are analyzed in the appropriate scientific context, increasing the Core's efficiency and effectiveness compared to general purpose data analysis services. The Biostatistics and Bioinformatics Core combines classical statistical techniques with contemporary Bayesian, machine learning and genomics methods to ensure that every research project, DRP and CEP awardee in the MSCP SPORE has access to the most appropriate analyses. The Core will also work closely with Core 1 to ensure that data flows between laboratories, clinics and analysts are efficient and that data and resource sharing can be effective and comprehensive.