ADMINISTRATIVE CORE - PROJECT SUMMARY The purpose of Administrative Core (AC) is to provide the organizational, administrative and fiscal management of this P01, to develop and implement plans for monitoring the progress, and to effectively coordinate and communicate within the P01. The AC is essential to ensure that this Program Project is able to successfully conduct clinical studies and physics and biological research at all the collaborating institutions. Successful conduct of research in a complex, multi-site program of this magnitude and significance requires centralized scientific and administrative oversight. Aims of the Administrative Core are: (1) Provide centralized scientific and administrative oversight, management and clerical support to all Projects and Cores; organize and conduct the Internal Steering Committee (ISC) and the annual External Advisory Board (EAB) meetings; and provide support for the weekly, monthly and as-needed telephone and web-based online conferences. (2) Develop and implement plans for effective coordination of research; facilitate the exchange of materials (e.g., biological samples), data, models and information; coordinate communication among researchers; monitor progress; and report progress to the ISC, EAB and the NCI at appropriate intervals. (3) Provide fiscal management support and financial control services to individual projects and cores to ensure funds are expended appropriately and provide aid as needed for personnel management. Drs. Theodore Hong (MGH) and Radhe Mohan (MDACC), the P01 MPIs, will direct this Core and review progress and decide policy matters relating to research priorities. The External Advisory Board, comprised of top scientists in the field, will meet with investigators annually to review scientific progress and the direction of research and make recommendations for the following year. The ISC, composed of the highly qualified senior faculty at MGH and MDACC, will meet twice annually and will provide feedback and ensure that resources for the conduct of the proposed research are available. There will be numerous regularly scheduled scientific and administrative meetings to coordinate activities at the multiple institutions involved to facilitate research and monitor progress.