The overall goal of the ‘Childhood Infections Research Program’ T32 (CHIRP) is to prepare MD Fellows and PhD postdoctoral scientists for careers as investigators in basic and clinical / translational research related to infections in children. The objectives of CHIRP are: 1) to identify the outstanding MD and PhD candidates committed to a research career related to infections of children; 2) to support mentored research training with experienced senior mentors and productive emerging mentors; 3) to implement a “career design by objective” program that establishes individualized timelines and pathways for training and long-term career development; 4) to utilize courses and degree programs relevant to the individualized training plan; and 5) to incorporate novel interdisciplinary training programs among MD and PhD trainees to create broad understanding of important questions and issues in childhood infections. CHIRP has identified 23 senior mentors in Pediatric Infectious Diseases, Pediatrics, Medicine, and Pathology, Microbiology & Immunology with sustained NIH funding coupled with a successful track record of mentoring early career scholars. Also, we have selected 8 ‘emerging mentors’, with funding and established trainees and productivity. Mentor research and training programs are in virology, bacteriology, vaccines, hospital infections, epidemiology, outcomes, and global health. MD trainees will be identified from Pediatric Infectious Diseases, other pediatric subspecialties and resident and recruitment. PhD applicants will be identified by application of externally and internally recruited PhD candidates of CHIRP mentors and broadly across Vanderbilt. A Program Director, Associate Directors, and Steering Committee of senior mentors and experts in diversity will direct the selection and ongoing evaluation of trainees and program progress. An Advisory Committee of three national leaders in Pediatric Infectious Diseases and diversity initiatives will review and provide recommendations for changes and improvements, including approaches to increase underrepresented minorities and women scholars. Evaluation of trainees will be based on required scholarship oversight committees, individual development plans, trainee progress reports, and compliance with requirements for training in responsible conduct of research and reproducibility. Ongoing program evaluation has led to improvements including the advisory committee and a new monthly “T32-Club” for trainees with discussions of RCR, reproducibility, diversity, research-in-progress, and trainee-selected topics relevant to success and challenges of research careers. Long-term program success will be based on outcomes of trainees in publications, career progress, and follow-on funding and will be assessed trainee evaluations and review by steering committee and advisory committee. CHIRP has been highly successful in recruiting, mentoring and establishing investigators in childhood infections, and we requ...