# Biospecimen and Pathology Core

> **NIH NIH U54** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $179,230

## Abstract

ABSTRACT – BIOSPECIMEN/PATHOLOGY CORE
The overarching goal of this SPORE is to understand the biological underpinnings of hyperactivated p21ras
pathway signals in the pathogenesis of childhood malignancies of neurofibromatosis type 1 and to bring new
therapies to the clinic. Each project explores this theme using a different disease model. However, all projects
interweave human, mouse and in vitro studies to identify factors that modify the effects of Ras. To ensure the
success of these studies, complementary cutting-edge technologies will be used to address key questions
related to disease susceptibility, likelihood of disease relapse, and risk for other malignancies.
The Biospecimen and Pathology Core will receive human and mouse samples from all four projects in the
SPORE. The core will also provide pathological review of all samples and will make these data available to all
SPORE investigators and the broader research community. The specific aims of this core are:
Aim 1: Maintain and update the DHART SPORE website as an effective internal and external
communication tool.
Aim 2: Utilize uniform biospecimen receipt, tracking and distribution procedures for samples collected as part
of DHART SPORE projects.
Aim 3: Apply uniform pathology protocols for the characterization of human and animal samples
collected as part of DHART SPORE projects.

## Key facts

- **NIH application ID:** 10270580
- **Project number:** 2U54CA196519-06A1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** TATIANA M. FOROUD
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $179,230
- **Award type:** 2
- **Project period:** 2015-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10270580

## Citation

> US National Institutes of Health, RePORTER application 10270580, Biospecimen and Pathology Core (2U54CA196519-06A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10270580. Licensed CC0.

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