PROJECT SUMMARY/ABSTRACT This new Institutional Training Grant (T32) application from the University of Texas Medical Branch (UTMB) will provide multidisciplinary and interprofessional research training for physician-scientists in emerging infectious diseases (EIDs). The ongoing risk and likelihood of facing outbreaks and epidemics caused by EIDs highlights a critical need for developing physician-scientists with trans-disciplinary skills in clinical medicine, epidemiology, field investigation, laboratory science, and biocontainment. The program capitalizes on world- class faculty expertise, longstanding institutional commitments, and unique research resources. It includes targeted recruitment of candidates at local, regional and national levels. Candidates will be physicians who are completing or have completed, an ACGME-certified residency or fellowship. One trainee per year will enter and complete 2-3 years of training during the 5-year program. Training includes instruction and mentorship in 1) team science; 2) research design, epidemiological methods, and biostatistics (MSc in Clinical Science); 3) EIDs and outbreak investigation; 4) clinical and research biocontainment/biosafety; 5) responsible conduct of research; 6) field epidemiology; and 7) scientific writing. Each of the trainees will apply their training by conducting translational research while receiving intensive scientific and career mentorship through a novel Team Science framework called individualized Multidisciplinary, Interprofessional Mentorship Team (iMIMT). Each iMIMT will include the trainee, a primary and secondary mentor (a PhD scientist and a MD scientist), and 2 or 3 peer or specialized knowledge mentors. iMIMTs will receive regular Team Science training and coaching. Instruction in grant writing will culminate in submission of an NIH career development application in the last year of training. Regular, but limited clinical responsibility will enable trainees to maintain clinical skills and learn how to manage a dual clinical-research career. Our 29 program faculty have productive translational research programs in EIDs and a record of successful mentoring. They are complemented by collaborating investigators from Peru, Colombia, Mexico, Dominican Republic, and Brazil. Additional program support faculty have specialized expertise for programmatic/operational support. The trainees' individualized development plan includes well-defined training activities, expected competencies, indicators of success, and a timeline for completion. Co-Program Directors and 3 Associate Program Directors will lead the program under Steering Committee governance. Sub-committees will oversee trainees' recruitment and selection, mentorship, and scientific progress. An External Advisory Committee will evaluate the program's progress annually. At completion, our trainees will have strong trans-disciplinary understanding of EIDs, will be grounded in research methods and outbreak investigation, ...