PROJECT SUMMARY: PATHOLOGY SHARED RESOURCE Together, the Tissue Sciences Facility (TSF) and Tissue Procurement Shared Resource (TPSR) make up the Pathology Core Facility, which was created to provide comprehensive tissue banking, histology, imaging and related instrumentation and expertise to members of the Fred and Pamela Buffett Cancer Center (BCC) investigators. The Tissue Sciences Facility (TSF) was created to provide comprehensive histology and imaging applications to Fred and Pamela Buffett Cancer Center (BCC) investigators. The Tissue Procurement Shared Resource (TPSR), also part of the Pathology Core Facility, was created to provide frozen and rapid autopsy samples to members of the Buffett Cancer Center. The availability of expert advice and services to both new and established investigators, including routine histology, paraffin and frozen sectioning, histochemical staining, routine and multiplex immunohistochemistry, in situ hybridization, digital imaging, project customization, and pathology consultation, are emphasized in the facility. These services provided by highly trained laboratory scientists offer comprehensive pathology support for basic science and translational research. Collaboration and pathological consultation are available to BCC investigators at all points in the research process by Pathology faculty.