# Imaging Core

> **NIH NIH P20** · UNIVERSITY OF NORTH DAKOTA · 2021 · $212,835

## Abstract

SUMMARY. The objective of this project is to support the imaging and image analysis needs of the COBRE
Phase 2 program while continuing to support the broader research community. All four Phase 2 Project Leaders
propose to identify and characterize the factors that control host responses to viral, bacterial, and parasitic
pathogens using confocal, fluorescence and electron microscopy and quantitative image analysis. The Core is
well equipped to meet these needs. Core equipment includes a multiphoton microscope for intravital microscopy,
a confocal microscope, two epifluorescence microscope systems, one capable of TIRF microscopy and both
equipped for live cell imaging, scanning and transmission electron microscopes, and a workstation with several
image analysis tools. The Core proposes four specific aims to ensure that COBRE investigators (Phase 2 and
Phase 1 Project Leaders) and the broader research community can meet their research goals. First, the Core
director and staff will collaborate with COBRE investigators and other members of the research community by
assisting with the development of experimental designs and microscopy approaches, analyzing microscopy
images, and interpreting data collected in the Core. Second, Core staff will provide training in equipment use,
microscopic imaging services, and educational resources to COBRE investigators and other members of the
research community. Third, the Core will provide image analysis software tools and expertise to support
quantitative microscopy studies by COBRE investigators and other members of the research community. Finally,
the Core will upgrade its equipment by replacing an outdated epifluorescence microscope and seeking funding
through the S10 Shared Instrumentation Grant Program to replace the Core Zeiss confocal microscope with a
new confocal microscope system. The outcome of these aims will be expansion of Core services, increased
Core research capabilities, new research opportunities for users and advancement of the Core’s goals to expand
the user base and achieve long-term sustainability.

## Key facts

- **NIH application ID:** 10270974
- **Project number:** 2P20GM113123-06
- **Recipient organization:** UNIVERSITY OF NORTH DAKOTA
- **Principal Investigator:** BRYON D GROVE
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $212,835
- **Award type:** 2
- **Project period:** 2016-05-13 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10270974

## Citation

> US National Institutes of Health, RePORTER application 10270974, Imaging Core (2P20GM113123-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10270974. Licensed CC0.

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