# Administrative Core

> **NIH NIH P50** · EMORY UNIVERSITY · 2021 · $183,759

## Abstract

Project Summary
This multi-project Center aims to establish a framework to understand the FMRP-mediated regulation of human
brain development and circuit functions at molecular, cellular and system circuitry levels using our established
human 2D and 3D model systems as well as mouse models. The Center will test the overall hypothesis that
FMRP regulates human brain development and circuit functions via translational regulation of novel mRNA
targets, which could serve as new therapeutic targets for fragile X syndrome. Our proposed Center brings
together an outstanding team of investigators from Emory University School of Medicine, Stanford University
School of Medicine, New York University Center for Neural Science, University of Pennsylvania Perelman School
of Medicine, and University of Southern California Department of Biomedical Engineering. Our investigators have
had ongoing and productive collaborations with each other for many years and have been highly cooperative
during the preparation of this application. The Administrative Core will serve as the foundation for a successful
collaborative effort through centralized coordination of the proposed Projects and the leveraging of existing
resources. A large collaborative research program such as this, which is designed to generate large datasets
that need to be analyzed and integrated over research projects at multiple sites, requires a focused and
dedicated effort to ensure success. The Administrative Core will assume primary responsibility for leading the
effort to maintain transparency, organization, and communication. The Administrative Core will be responsible
for facilitating the sharing of resources and data among investigators, ensuring timely progression towards
milestones, sharing results with the scientific community and the general public, and conducting financial and
regulatory oversight. We are committed to identifying innovative, state-of-the-art tools to facilitate this
collaborative effort to reach our overarching goal. Using an array of collaborative organization products, we will
be able to ensure open communication channels, secure sites for data deposition, and transparent operation of
the Center. In summary, the Administrative Core is the foundation for a successful collaborative effort through
centralized coordination of the proposed Projects and leverages existing resources within the partner institutions.
Emory University, the host institution, offers a vast array of resources and expertise that we can access to
facilitate the effective administration of this Center. We believe that our coordinated effort will create scientific
synergy and significantly advance our understanding of FMRP-mediated gene regulation in human brain
development and enable novel therapeutic development for fragile X syndrome.

## Key facts

- **NIH application ID:** 10271306
- **Project number:** 5P50HD104458-02
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** PENG JIN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $183,759
- **Award type:** 5
- **Project period:** 2020-09-25 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10271306

## Citation

> US National Institutes of Health, RePORTER application 10271306, Administrative Core (5P50HD104458-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10271306. Licensed CC0.

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