# RADx-UP CDCC

> **NIH NIH U24** · DUKE UNIVERSITY · 2021 · $36,243,390

## Abstract

ABSTRACT
There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in
historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To
address this need the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) program will
support Community-Engaged Testing Research Projects and Social, Ethical and Behavioral Implications
(SEBI) Research Projects to understand SARS-CoV-2 infection patterns and increase access and
effectiveness of diagnostic methods in underserved and/or vulnerable populations. The Duke Clinical Research
Institute (DCRI), the UNC Center for Health Equity Research (CHER), and Community-Campus Partnerships
for Health (CCPH) propose to serve as the Coordination and Data Collection Center (CDCC) to provide
management, direction, and overall coordination of the RADx-UP consortium. Together, our multidisciplinary
experience in project coordination; COVID-19 thought leadership; regulatory science; community engagement;
health equity research; social justice; adult and child research; statistics; data science; and clinical research
informatics will advance the objectives of the projects in the RADx-UP Program. Our overarching goal is to
implement a community-centered approach and establish an effective, flexible, participatory, and sustainable
CDCC that will serve as the infrastructure to maximize the community impact of projects in the RADx-UP
Program. To achieve this vision, we will establish a program framework comprised of four cores. Our
Administration and Coordination Core, in collaboration with NIH scientific staff, will facilitate the work of the
RADx-UP Program in overarching administrative management. The COVID-19 Testing Core will advise and
guide COVID-19 testing protocols; curate emergent testing data; and administer the Rapid Pilot Studies
Program. The Community and Health System Engagement Core will support a community of practice across
the RADx-UP Program; provide support in exchanging best practices across communities on recruitment,
engagement, and retention of study participants; and coordinate the dissemination of study findings from
RADx-UP projects. The Data Science and Biostatistics Core will manage data collection, integration, and
sharing for the RADx-UP Program including merging and harmonization of multiple and diverse data sources
and provide data standards, data collection design, and biostatistics consulting services. The RADx-UP CDCC
goals will be met using established infrastructure and subject matter experts and will be customized to meet
the variable needs of the RADx-UP community. Using the highest research standards, our team will
accomplish the goals set out by the NIH in managing this critically important collaborative effort.

## Key facts

- **NIH application ID:** 10271490
- **Project number:** 4U24MD016258-02
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Michael Cohen-Wolkowiez
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $36,243,390
- **Award type:** 4N
- **Project period:** 2020-09-27 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10271490

## Citation

> US National Institutes of Health, RePORTER application 10271490, RADx-UP CDCC (4U24MD016258-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10271490. Licensed CC0.

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