PROJECT SUMMARY Structural changes on the order of microns can have a profound effect on visual function. Because of this, the ability to study the eye often requires high-quality histological, molecular, and ultrastructural data. The goal of the Molecular Imaging Core is to provide vision researchers at The University of Iowa with access to the specialized equipment, facilities and experienced staff necessary to collect these data. These services and expertise will be available without charge to NEI R01-funded investigators and new investigators whose research aligns with the mission of the NEI and IVR. They will be available to investigators with funding from other NIH agencies as well. This will accelerate the pace of vision research at The University of Iowa by providing access to high-quality histological and ultrastructural data and procedures.