BIOINFORMATICS SHARED RESOURCE Project Summary/Abstract The UNMCCC Bioinformatics Shared Resource supports basic and advanced bioinformatics needs, including analysis of high throughput genomic sequencing, high-throughput drug screening cheminformatics, target analytics and pharmacoinformatics. Faculty Director Yan Guo, Ph.D. (CMO) supervises the Resource with two additional associate directors, Jeremy Edwards Ph.D. (CMO) and Tudor Opera Ph.D. (CT). The Bioinformatics Shared Resource is operated by two full-time staff. The Cancer Center Research Administration manages the Resource, which provides several types of services including quality control, processing and analysis of newly generated genomics data, secondary analysis of existing genomics data, study design, manuscript and grant support. Reservations, billing and usage are tracked through an in-house developed SQL database. The Resource Director and staff worked closely with the Research Programs to develop new methodologies that promote innovative basic and genomics research goals and the Resource actively facilitates and disseminates information about new bioinformatics technologies by maintaining an up-to-date web page and by giving presentations/seminars at UNMCCC meetings and retreats. During the previous 5-yr project period, 35 PIs used services from the Bioinformatics Shared Resources, a substantial increase from the 24 users from the previous period. Among them, 30 were UNMCCC members from the three Research Programs. Also during the last cycle, the Bioinformatics Shared Resources assisted with the publication of 20 scientific manuscripts. Furthermore, the Bioinformatics Shared Resource supported the submission of 28 national grants (20 NCI and 8 non-NCI). Nine of them were funded and are currently supporting activites in the Bioinformatics Shared Resource. Nine grants are currently pending review.