Abstract/Project Summary The Stanford Breast Metastasis Center (SBMC) Administrative Core will operate by upholding the principle that our success relies on a well coordinated and focused multidisciplinary team executing premier research. Our core team has an established track record of working on large scale projects with scientific investigators from multiple fields, including cancer biology, immunology, functional genomics, computational biology, bioinformatics and statistics, breast medical oncology, pathology, surgery. Through our Administrative Core, we will provide oversight that identifies and responds to short-term and long-term needs by executing three aims. Our first aim is to establish and maintain an effective and responsive organizational structure that provides proper communication and coordination of activities within the NCI Metastasis Network. For internal oversight, we will convene an Executive Committee, including patient advocates, External Advisory Committee, Internal Advisory Committee, and Steering Committee that will meet regularly to review current progress, make recommendations and monitor future progress. All SBMC investigators and staff will be expected to attend bi-weekly SBMC meetings where we will have general announcements by PIs, Project Leads and Core Leads, review our milestones, hear updates and an in-depth presentation from one of our investigators followed by discussion. We will maintain updated mailing lists and a website to disseminate announcements, archive summary notes from meetings, host a calendar of activities and provide links to data and model repositories. Our second aim is to establish and maintain a communication and logistics strategy for transparent and responsive interactions within the SBMC the NCI MetNet and the broader scientific community. To foster exchange of data and methods within other centers comprising the MetNet, we will actively participate in annual MetNet investigator meetings and contribute to the activities of the MetNet by organizing and participating in collaborative activities and working groups. Our third aim is to facilitate the evaluation of Center interim milestones and, if needed, implement processes to revise milestones with NCI MetNet Program Manager approval. We will monitor progress at bi- weekly SBMC team meetings through our SBMC Milestones Dashboard, which will summarize progress in our three Projects and Cores. We will also report progress on milestones at NCI MetNet annual meeting. Thirdly, we will host an onsite evaluation of our Center’s performance during annual NCI Site Reviews. Finally, in the unlikely event that we experience a delay in meeting our milestones, we will engage a resolution strategy that will involve our team and Steering Committee, and, as needed, the EAC, IAC, colleagues in other MetNet Centers and the NCI.