# A new PET neuroimaging probe for sigma 1 receptor

> **NIH NIH R03** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $250,640

## Abstract

Project Summary
Sigma 1 receptor (σ1R) has been implicated in multiple functions and associated with various human diseases,
including brain diseases/disorders. σ1R has been reported to interact with numerous neurotransmitter receptors
and ion channels, and involved in diverse basic biochemical processes and pathological conditions related to
neurodegeneration, pain sensitization, psychiatric disorders, and drug addiction. Therefore, it is important to
have a tool for non-invasive measurement of σ1R expression and function in vivo, and PET imaging would be
an ideal tool.
Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes
in animals or in man. The development of techniques for visualizing σ1R in vivo represents a key step in
understanding both the normal function and pathophysiology of σ1R in brain. Moreover, these techniques will
accelerate the discovery of small molecule therapeutics that selectively interacts with σ1R. The project is
designed to validate a novel PET imaging probe, [18F]CNY-05, for σ1R imaging in rodents and non-human
primates.

## Key facts

- **NIH application ID:** 10272877
- **Project number:** 1R03DA054126-01
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Changning Wang
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $250,640
- **Award type:** 1
- **Project period:** 2021-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10272877

## Citation

> US National Institutes of Health, RePORTER application 10272877, A new PET neuroimaging probe for sigma 1 receptor (1R03DA054126-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10272877. Licensed CC0.

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