# Inflammation-Induced CNS Glutamate as a Function of Depression in Middle Age

> **NIH NIH R01** · EMORY UNIVERSITY · 2021 · $129,073

## Abstract

PROJECT SUMMARY
The aims and goals are similar to those proposed in the parent application. Briefly, we plan to measure 1) CNS
glutamate using single voxel and chemical-shift, multivoxel, MRS, 2) microstructural white matter integrity
using diffusion tensor imaging/tract-based spatial statistics and myelin mapping, 3) peripheral and central
biomarkers of inflammation and 4) depressive symptoms and cognition in 65 medication-free depressed and
35 controls aged 35-65. A sample of 80 subjects (55 depressed, 25 controls) have already been studied. We
propose support to recruit 10 more depressed and 10 more controlled subjects.
Issues specific to this request: Our study has faced closure between the months of March-September 2020
due to COVID-19-related shutdown. However, all staff salaries have been paid in full due to understandable
and compassionate reasons. We request recouping the salary paid for the past 7 months and restart up costs.
The full impact of the study could be fully realized by augmenting the sample with 20 more patients – resulting
in a completion sample of 100. We have provided power analysis in support of this conclusion.

## Key facts

- **NIH application ID:** 10273670
- **Project number:** 3R01MH107033-05S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Ebrahim Haroon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $129,073
- **Award type:** 3
- **Project period:** 2016-02-01 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10273670

## Citation

> US National Institutes of Health, RePORTER application 10273670, Inflammation-Induced CNS Glutamate as a Function of Depression in Middle Age (3R01MH107033-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10273670. Licensed CC0.

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